Abstract | BACKGROUND: METHODS: In this study, we looked to using the mass spectrometry mediated spatial metabolomics technique to simultaneous examine hundreds of metabolites in an untargeted fashion. Additionally, metabolic profiles were compared between six subregions within the HCC tissue to collect spatial information. RESULTS: Through those metabolites, altered metabolic pathways in LC and HCC were identified. Specifically, the amino acid metabolisms and the glycerophospholipid metabolisms experienced the most changes. Many of the altered metabolites and metabolic pathways were able to be connected through the urea cycle. CONCLUSIONS: The identification of the key metabolites and pathways can expand our knowledge on HCC metabolic reprogramming and help us exam potential biomarkers for earlier detection of the malignant disease progression.
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Authors | Michelle Junyi He, Wenjun Pu, Xi Wang, Xiaoni Zhong, Dong Zhao, Zhipeng Zeng, Wanxia Cai, Jiayi Liu, Jianrong Huang, Donge Tang, Yong Dai |
Journal | Cancer cell international
(Cancer Cell Int)
Vol. 22
Issue 1
Pg. 366
(Nov 24 2022)
ISSN: 1475-2867 [Print] England |
PMID | 36419080
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s). |