Abstract | PURPOSE: Turmeric has renop rotective effects that can act to reduce oxidative stress and inflammation in hemodialysis (HD) patients. Piperine has been indicated as a bioavailability enhancer of turmeric and consequently of its biological effects. However, data on the efficacy of the turmeric/ piperine combination in HD patients are limited. We aimed to verify whether turmeric supplementation in combination with piperine has a superior effect to turmeric alone in increasing antioxidant capacity and reducing oxidative stress and inflammation in HD patients. METHODS: RESULTS: There was a reduction in the MDA and ferritin levels in the turmeric/ piperine group and in the comparison between groups at the end of the study [MDA: -0.08(-0.14/0.01) nmol/mL versus -0.003(-0.10/0.26) nmol/mL, p = 0.003; ferritin: -193.80 ± 157.29 mg/mL versus 51.99 ± 293.25 mg/mL, p = 0.018]. In addition, GPx activity reduced in the turmeric group (p = 0.029). No changes were observed for CAT, GR, and hs-CRP. CONCLUSION: Turmeric plus piperine was superior to turmeric alone in decreasing MDA and ferritin levels. The use of a combination of turmeric and piperine as a dietary intervention may be beneficial for modulating the status oxidative and inflammation in HD patients. BRAZILIAN REGISTRY OF CLINICAL TRIALS NUMBER: RBR-2t5zpd; Registration Date: May 2, 2018.
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Authors | Nayara Cristina Freitas E Silva-Santana, Hellen Christina Neves Rodrigues, Tatiane Fagundes Pereira Martins, Clarice Carneiro Braga, Marina Alves Coelho Silva, Luiz Carlos da Cunha, Ana Tereza Vaz de Souza Freitas, Nara Aline Costa, Maria do Rosário Gondim Peixoto |
Journal | Free radical biology & medicine
(Free Radic Biol Med)
Vol. 193
Issue Pt 2
Pg. 648-655
(11 20 2022)
ISSN: 1873-4596 [Electronic] United States |
PMID | 36370961
(Publication Type: Randomized Controlled Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 Elsevier Inc. All rights reserved. |
Chemical References |
- piperine
- Antioxidants
- C-Reactive Protein
- Ferritins
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Topics |
- Curcuma
(metabolism)
- Antioxidants
(therapeutic use, metabolism)
- C-Reactive Protein
(metabolism)
- Oxidative Stress
- Inflammation
(drug therapy)
- Renal Dialysis
(adverse effects)
- Dietary Supplements
- Ferritins
(metabolism)
- Double-Blind Method
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