Abstract | INTRODUCTION: MATERIAL AND METHODS: We enrolled 134 subjects with COVID-19 and 58 normal healthy subjects for the study. We measured serum ATX levels longitudinally in COVID-19 patients and investigated the time course and the association with severity and clinical parameters. RESULTS: The serum ATX levels were reduced in all patients with COVID-19, irrespective of the disease severity, and were negatively associated with the serum CRP, D-dimer, and anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody levels. DISCUSSION: Considering the biological properties of LPAs in the pulmonary inflammation and fibrosis, modulation of ATX might be compensatory biological responses to suppress immunological overreaction especially in the lung, which is an important underlying mechanism for the mortality of the disease. CONCLUSIONS:
COVID-19 patients showed a decrease in the serum levels of ATX, irrespective of the disease severity. Key MessagesAutotaxin (ATX) is an enzyme involved in the synthesis of lysophosphatidic acid (LPA), which has been reported to be involved in pulmonary inflammation and fibrosis. Patients with COVID-19 show decrease in the serum levels of ATX. Modulation of ATX might be compensatory biological responses to suppress immunological overreaction.
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Authors | Takuya Shimura, Makoto Kurano, Koh Okamoto, Daisuke Jubishi, Hideki Hashimoto, Kuniyuki Kano, Koji Igarashi, Satoshi Shimamoto, Junken Aoki, Kyoji Moriya, Yutaka Yatomi |
Journal | Annals of medicine
(Ann Med)
Vol. 54
Issue 1
Pg. 3189-3200
(12 2022)
ISSN: 1365-2060 [Electronic] England |
PMID | 36369824
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lysophospholipids
- Phosphoric Diester Hydrolases
- alkylglycerophosphoethanolamine phosphodiesterase
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Topics |
- Humans
- COVID-19
(blood)
- Fibrosis
- Lung
- Lysophospholipids
- Phosphoric Diester Hydrolases
(blood)
- SARS-CoV-2
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