The cardioprotective potentials and the involved mechanisms of phenolic acids in drug-induced cardiotoxicity.

Abstract

Cardiotoxicity is one of the major safety concerns in the use of drug and is the most common reason for drug removal from the market. At present, several drugs that have been recognized as the clinically effective drug have been reported to be associated with a high risk of cardiotoxicity during clinical use. The most representative ones are doxorubicin, arsenic trioxide, isoproterenol, cyclophosphamide, etc. The adverse effects seriously affect the human health and limit the clinical application of the drugs mentioned above. Over the past years, many strategies have been carried out to prevent the occurrence of drug-induced cardiotoxicity, including early detection of cardiotoxicity by biomarkers, limitation of doses, changing of drug-delivery way, combining with cardioprotective agent. Among them, combining with cardioprotective agent has gained increased interest and has been considered as a promising approach for continued treatment. Therefore, looking for effective cardioprotective agent to avoid the occurrence of drug-induced cardiotoxicity has become a great challenge for many researchers. Interestingly, some phenolic acids compounds from natural plants have been demonstrated to establish a significant protective effect in drug-induced cardiotoxicity. In this work, we reviewed the cardioprotective potentials and the involved mechanisms of phenolic acids in drug-induced cardiotoxicity. To provide a reference for the further application of phenolic acids in the prevention of drug-induced cardiotoxicity.

• Authors: Xianfeng Liu, Ruimin Tian, Honglin Tao, Jiasi Wu, Lu Yang, Yi Zhang, Xianli Meng
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 936 Pg. 175362 (Dec 05 2022) ISSN: 1879-0712 [Electronic] Netherlands
• PMID: 36343692 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Chemical References

• Cardiotonic Agents
• phenolic acid
• Hydroxybenzoates

Topics

• Humans
• Cardiotoxicity (etiology, prevention & control)
• Cardiotonic Agents (pharmacology, therapeutic use)
• Hydroxybenzoates
• Drug-Related Side Effects and Adverse Reactions