Abstract | INTRODUCTION: AIMS: METHODS: HA levels were scored using affinity histochemistry in 137 NSCLC samples stratified by HA score ≤10, 11-20, 21-30, and >30 with HA-high defined as ≥25% expression in the extracellular matrix (ECM) of the tumor surface area. Overall survival (OS) and time to progression from initiation of taxane therapy ( TTP) were compared using log-rank tests based on HA score. RESULTS: Of 122 patients with recurrent/metastatic NSCLC, 93 had mean HA scores that were not significantly different across clinicopathologic variables. Frequency of HA-high tumors did not differ by histology (34/68 adenocarcinomas vs. 12/25 squamous tumors, Fisher's p = 1.0000). Median OS for recurrent/metastatic adenocarcinoma was 35.5 months (95%, 23.6-50.3) vs. 17.9 months for squamous (95%, 12.7-37.0, log-rank test, p = 0.0165). OS was not significantly different by HA quartiles, high or low (<25) HA score and tumor histology, and HA biopsy site (all p > 0.05). Median TTP (n = 98) significantly differed by HA quartile (2.8 months for HA score ≤10; 5.0 months for 11-20; 7.9 months for 21-30; 3.9 months for >30, p = 0.0265). Improved TTP trended in HA-high over HA-low tumors (n = 98, p = 0.0911). CONCLUSION: In this NSCLC cohort, tumor HA level represents a potential biomarker for TTP, which remains a cornerstone of NSCLC therapy. Further validation is warranted to identify the HA accumulation threshold associated with clinical benefit.
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Authors | Jun Gong, Michelle Guan, Haesoo Kim, Natalie Moshayedi, Sejal Mehta, Galen Cook-Wiens, Brent K Larson, Jenny Zhou, Rishi Patel, Isaac Lapite, Veronica R Placencio-Hickok, Richard Tuli, Ronald B Natale, Andrew E Hendifar |
Journal | Oncotarget
(Oncotarget)
Vol. 13
Pg. 1202-1214
(Nov 02 2022)
ISSN: 1949-2553 [Electronic] United States |
PMID | 36342462
(Publication Type: Journal Article)
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Chemical References |
- Hyaluronic Acid
- Biomarkers
- Biomarkers, Tumor
|
Topics |
- Humans
- Carcinoma, Non-Small-Cell Lung
(pathology)
- Hyaluronic Acid
(metabolism)
- Retrospective Studies
- Lung Neoplasms
(pathology)
- Neoplasm Recurrence, Local
- Adenocarcinoma
(metabolism)
- Carcinoma, Squamous Cell
- Biomarkers
- Biomarkers, Tumor
(metabolism)
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