Abstract | BACKGROUND: Severe oral mucositis associated with cancer therapy is a frequent complication that may affect a patient's systemic condition, resulting in interruption and/or prolongation of cancer therapy. Dentoxol® is a medical solution in the form of a mouthwash that has been shown to result in statistically significant improvement in the prevention of severe oral mucositis. However, knowing the measures of the clinical significance of this therapy is important for accurate decision-making. AIM: To describe the clinical impact of Dentoxol® use in severe oral mucositis. METHODS: Clinical significance was measured using the results obtained in a randomized controlled clinical trial previously conducted by the same group of researchers. The measures of clinical significance evaluated were the absolute risk or incidence, relative risk, absolute risk reduction, relative risk reduction, number needed to treat, and odds ratio. RESULTS: The data obtained show that the impact of Dentoxol® on reducing the severity of oral mucositis has important clinical relevance. CONCLUSION:
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Authors | Sebastián Solé, Sergio Becerra, Claudia Carvajal, Piero Bettolli, Hernán Letelier, Alejandro Santini, Lorena Vargas, Alexander Cifuentes, Francisco Larsen, Natalia Jara, Jorge Oyarzún, Eva Bustamante, Benjamín Martínez, David Rosenberg, Tomas Galván |
Journal | World journal of clinical oncology
(World J Clin Oncol)
Vol. 13
Issue 10
Pg. 813-821
(Oct 24 2022)
ISSN: 2218-4333 [Print] United States |
PMID | 36337310
(Publication Type: Clinical Trial)
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Copyright | ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |