We have previously shown that
adenosine A1AR antagonists,
adenosine A2aAR antagonists, and
caffeine have significant inhibitory effects on the activation and proliferation of hepatic stellate cells in alcoholic
liver fibrosis. Many recent studies have found that moderate
coffee consumption is beneficial for various
liver diseases. The main active ingredient of
coffee is
caffeine, which is a natural non-selective
adenosine receptor antagonist. Moreover, numerous preclinical epidemiological studies and clinical trials have examined the association between frequent
coffee consumption and the risk of developing different
liver diseases. In this review, we summarize and analyze the prophylactic and
therapeutic effects of
caffeine on various
liver diseases, with an emphasis on cellular assays, animal experiments, and clinical trials. To review the prevention and treatment effects of
caffeine on different
liver diseases, we searched all literature before 19 July 2022, using "
caffeine" and "
liver disease" as keywords from the PubMed and ScienceDirect databases. We found that moderate
coffee consumption has beneficial effects on various
liver diseases, possibly by inhibiting
adenosine binding to its receptors.
Caffeine is a potential
drug for the prevention and treatment of various
liver diseases.