Abstract | INTRODUCTION: MATERIAL AND METHODS: We retrospectively reviewed resected LUAD samples from 8437 patients and identified 5358 EGFR-mutated (EGFRm) cases. Of these, 4847 had classical mutations, while 511 had atypical mutations. For further survival analysis, propensity score matching, Kaplan-Meier curve, and Cox regression analyses were conducted. RESULTS: Of the 511 patients with atypical EGFRm LUAD, 131 patients had compound mutations. The frequency of exon 20 insertion (20-ins), G719X, L861Q, S768I, and de novo T790M were 30.3%, 32.7%, 21.9%, 9.2%, and 11.4%, respectively. These patients included a higher proportion of males than those with classical EGFRm LUAD. Between the 483 matched pairs of the classical and atypical EGFRm patients, no significant difference emerged in disease-free survival (DFS) (p = 0.476). Patients with the L861Q mutation had the poorest DFS among those with atypical EGFRm LUAD (p = 0.005). Cox regression analyses revealed that the L861Q mutation was an independent prognostic factor for DFS in 487 patients with solely atypical EGFRm LUAD. In addition, adjuvant chemotherapy did not improve the DFS for those patients, whether in stage IB (p = 0.638) or II-III (p = 0.505) of the disease. CONCLUSION: The L861Q mutation is an independent prognostic factor for DFS in patients with atypical EGFRm LUAD after complete resection who would not benefit from adjuvant chemotherapy regardless of disease stage.
|
Authors | Yunlang She, Shenghui Li, Jiajun Deng, Yijiu Ren, Mengmeng Zhao, Yifan Zhong, Yiming He, Qiankun Chen, Deping Zhao, Yuming Zhu, Likun Hou, Chunyan Wu, Dong Xie, Chang Chen |
Journal | European journal of cancer (Oxford, England : 1990)
(Eur J Cancer)
Vol. 177
Pg. 53-62
(12 2022)
ISSN: 1879-0852 [Electronic] England |
PMID | 36323053
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2022 Elsevier Ltd. All rights reserved. |
Chemical References |
- EGFR protein, human
- ErbB Receptors
|
Topics |
- Humans
- Male
- Adenocarcinoma of Lung
(genetics, surgery, drug therapy)
- ErbB Receptors
(genetics)
- Lung Neoplasms
(genetics, surgery, drug therapy)
- Mutation
- Prognosis
- Retrospective Studies
|