Bacterial infections accompanied with wound healing often lead to more serious health hazards to patients. Therefore, it is urgent to explore a
wound dressing that can promote
wound repair while possessing antibacterial capability. Here, we constructed a multifunctional
hydrogel dressing by a redox-initiated cross-linking reaction of methacrylated
hyaluronic acid (HAMA), 5,10,15,20-tetra (4-methacrylate phenyl)
porphyrin (TPP), and
dopamine methacrylamide (DMA), named HAMA-TPP-DMA, with broad-spectrum photodynamic antibacterial capability, where the aggregation of TPP
photosensitizer units could be greatly inhibited to produce more
singlet oxygen. The
hydrogel has excellent biodegradability and biocompatibility, providing favorable conditions for wound healing. Furthermore, the incorporation of
dopamine into the
hydrogel gives the
wound dressing with enhanced adhesiveness, benefiting for the
wound repair. More importantly, the antibacterial experiments in vitro and mice
wound models in vivo showed that the HAMA-TPP-DMA
hydrogel can significantly resist bacteria and accelerate the wound healing in mice (the closure rate > 98% after 15 days). Thus, this
hydrogel dressing with superior antibacterial
infection and wound healing capability provides a promising strategy in
wound repair.