Abstract | BACKGROUND: METHODS: TEIC, human serum albumin (HSA), and IL-6 were incubated with pieces of hemofilter membranes and adsorption rates were calculated. The CLCHDF , diafiltration rate, and adsorption rate of TEIC were calculated using an in vitro CHDF circuit model. RESULTS: The adsorption rates of TEIC onto the pieces of PMMA and AN69ST membranes ranged from 15.0% to 100% and from -10% to 5%, respectively. The adsorption rate of IL-6 was similar with or without TEIC. The CLCHDF and adsorption rate of TEIC under PMMA-CHDF depended on HSA, but not on effluent flow rate (Qe). The CLCHDF under AN69ST-CHDF depended on HSA and Qe. The observed CLCHDF under AN69ST-CHDF was similar to the predicted value (the product of Qe and the plasma unbound fraction). The observed CLCHDF under PMMA-CHDF was 2.0-7.8 times greater than the predicted value. CONCLUSIONS: Adsorption mainly contributes to the CLCHDF of TEIC using PMMA membranes, whereas diafiltration mainly contributes to the CLCHDF of TEIC using AN69ST membranes. TEIC adsorption might not affect the adsorption of IL-6 onto PMMA membrane.
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Authors | Mifuyu Sawada, Masashi Uchida, Shingo Yamazaki, Tatsuya Suzuki, Takaaki Suzuki, Itsuko Ishii |
Journal | Artificial organs
(Artif Organs)
Vol. 47
Issue 4
Pg. 667-679
(Apr 2023)
ISSN: 1525-1594 [Electronic] United States |
PMID | 36310410
(Publication Type: Journal Article)
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Copyright | © 2022 International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC. |
Chemical References |
- Teicoplanin
- Interleukin-6
- Polymethyl Methacrylate
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Topics |
- Humans
- Teicoplanin
- Hemodiafiltration
- Interleukin-6
- Polymethyl Methacrylate
- Renal Dialysis
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