Abstract |
CCAAT/enhancer-binding proteins (C/EBPs) are a family of at least six identified transcription factors that contain a highly conserved basic leucine zipper domain and interact selectively with duplex DNA to regulate target gene expression. C/EBPs play important roles in various physiological processes, and their abnormal function can lead to various diseases. Recently, accumulating evidence has demonstrated that aberrant C/EBP expression or activity is closely associated with the onset and progression of fibrosis in several organs and tissues. During fibrosis, various C/EBPs can exert distinct functions in the same organ, while the same C/EBP can exert distinct functions in different organs. Modulating C/EBP expression or activity could regulate various molecular processes to alleviate fibrosis in multiple organs; therefore, novel C/EBPs-based therapeutic methods for treating fibrosis have attracted considerable attention. In this review, we will explore the features of C/EBPs and their critical functions in fibrosis in order to highlight new avenues for the development of novel therapies targeting C/EBPs.
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Authors | Lexun Wang, Jiaojiao Feng, Yanyue Deng, Qianqian Yang, Quxing Wei, Dewei Ye, Xianglu Rong, Jiao Guo |
Journal | Research (Washington, D.C.)
(Research (Wash D C))
Vol. 2022
Pg. 9891689
( 2022)
ISSN: 2639-5274 [Electronic] United States |
PMID | 36299447
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2022 Lexun Wang et al. |