Abstract | BACKGROUND: RESULTS: 53 COPD and 82 non- COPD individuals were followed-up on a maximum of four visits conducted from August 2016 to September 2017 in Beijing, China. Compared to non- COPD individuals, the association between exposure to ambient ultrafine particles (UFPs) during the 3-8 days preceding clinical visits and the TxB2 serum concentration was significantly stronger in COPD patients. For example, a 103/cm3 increase in the 6-day average UFP level was associated with a 25.4% increase in the TxB2 level in the COPD group but only an 11.2% increase in the non- COPD group. The association in the COPD group remained robust after adjustment for the levels of fine particulate matter and gaseous pollutants. Compared to the non- COPD group, the COPD group also showed greater increases in the serum concentrations of 12-HETE (16.6% vs. 6.5%) and 15-HETE (9.3% vs. 4.5%) per 103/cm3 increase in the 6-day UFP average. The two lipid peroxidation products mediated 35% and 33% of the UFP-associated increase in the TxB2 level of COPD patients. UFP exposure was also associated with the increased levels of IL-8, MCP-1, MIP-1α, MIP-1β, TNF-α, and IL-1β in COPD patients, but these inflammatory biomarkers did not mediate the TxB2 increase. CONCLUSIONS: Short-term exposure to ambient UFPs was associated with a greater pro-thrombotic change among patients with COPD, at least partially driven by lipoxygenase-mediated pathways following exposure. Trial registration ChiCTR1900023692 . Date of registration June 7, 2019, i.e. retrospectively registered.
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Authors | Teng Wang, Xi Chen, Haonan Li, Wu Chen, Yifan Xu, Yuan Yao, Hanxiyue Zhang, Yiqun Han, Lina Zhang, Chengli Que, Jicheng Gong, Xinghua Qiu, Tong Zhu |
Journal | Particle and fibre toxicology
(Part Fibre Toxicol)
Vol. 19
Issue 1
Pg. 65
(10 24 2022)
ISSN: 1743-8977 [Electronic] England |
PMID | 36280873
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Particulate Matter
- Chemokine CCL2
- Tumor Necrosis Factor-alpha
- Air Pollutants
- Chemokine CCL3
- Chemokine CCL4
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
- Interleukin-8
- Biomarkers
- Lipoxygenases
- Thromboxanes
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Topics |
- Adult
- Humans
- Particulate Matter
(toxicity)
- Chemokine CCL2
- Tumor Necrosis Factor-alpha
- Air Pollutants
(toxicity, analysis)
- Lipid Peroxidation
- Chemokine CCL3
- Chemokine CCL4
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
- Interleukin-8
- Air Pollution
- Pulmonary Disease, Chronic Obstructive
(chemically induced)
- Inflammation
(chemically induced)
- Biomarkers
- Lipoxygenases
- Thromboxanes
- Environmental Exposure
(analysis)
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