Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model.

Abstract

In order to investigate the effects of clopidogrel rehabilitation on the levels of cardiac protein kinase C (PKC), cardiac heat shock protein 70 (HSP70), and cardiac index (CI) in rats with myocardial ischemia-reperfusion injury (MIRI), sixty Wistar rats are randomly divided into three groups (sham operation group, model group, and clopidogrel group), with 20 rats in each group. The clopidogrel group is given clopidogrel by gavage, and the sham operation group and the model group are given the same amount of normal saline by gavage. The experimental results show that compared with the model group, the clopidogrel group has clear horizontal lines and cell edema. The myocardial infarction rate, creatine kinase-MB (CK-MB), and malondialdehyde (MDA) of the model group and clopidogrel group in the control sham operation group significantly increase.

• Authors: Qiaoyan Ma, Lizhong Wang, Hongyan Ma, Qian Cao, Jiagui Ma
• Journal: BioMed research international (Biomed Res Int) Vol. 2022 Pg. 5823276 ( 2022) ISSN: 2314-6141 [Electronic] United States
• PMID: 36277878 (Publication Type: Journal Article, Retracted Publication)
• Copyright: Copyright © 2022 Qiaoyan Ma et al.

Chemical References

• Clopidogrel
• Creatine Kinase
• HSP70 Heat-Shock Proteins
• Malondialdehyde
• Protein Kinase C

Topics

• Animals
• Rats
• Clopidogrel
• Creatine Kinase
• HSP70 Heat-Shock Proteins (metabolism)
• Malondialdehyde
• Myocardial Reperfusion Injury (drug therapy)
• Protein Kinase C
• Rats, Wistar