Abstract | OBJECTIVE: The aim of this study is to investigate effects of cisplatin preadministration on oral ulcerative mucositis-induced nociception by using an experimental model of rats. DESIGN: After two rounds of cisplatin administration, oral ulcers developed with topical acetic acid treatment in rats. Spontaneous mouth rubbing behavior was observed as spontaneous nociceptive behavior in a plastic cage. Head-withdrawal behavior was observed as mechanical allodynia by using von Frey test in the oral mucosa of conscious rats. Bacterial invasion and inflammatory cell infiltration into oral ulcerative region and systemic leukocyte phagocytic activity were assessed. RESULTS: CONCLUSIONS: These results suggest that cisplatin preadministration suppresses spontaneous nociception in oral ulcerative region, due to antiinflammatory effects by enhancement of leukocyte phagocytic activity, but exaggerates mechanical allodynia due to oxidative stress with N- formyl peptide receptor 1 activation. The suppression of spontaneous nociception is one of the advantages of cisplatin treatment for head and neck cancer patients although the exaggerated allodynia is a serious symptom.
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Authors | Chihiro Nakatomi, Suzuro Hitomi, Kiichiro Yamaguchi, Chia-Chien Hsu, Nozomu Harano, Koichi Iwata, Kentaro Ono |
Journal | Archives of oral biology
(Arch Oral Biol)
Vol. 144
Pg. 105572
(Dec 2022)
ISSN: 1879-1506 [Electronic] England |
PMID | 36265393
(Publication Type: Journal Article)
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Copyright | Copyright © 2022. Published by Elsevier Ltd. |
Chemical References |
- Cisplatin
- Receptors, Formyl Peptide
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Topics |
- Rats
- Animals
- Cisplatin
(adverse effects)
- Nociception
- Hyperalgesia
(chemically induced)
- Oral Ulcer
(chemically induced, drug therapy)
- Receptors, Formyl Peptide
- Mucositis
(chemically induced)
- Stomatitis
(drug therapy, chemically induced)
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