Abstract | PURPOSE: METHODS: This retrospective single-center, propensity-matched cohort study examined healthcare utilization outcomes for patients who received subcutaneous casirivimab and imdevimab at a pharmacist-led clinic of an academic health system. Eligible patients were treated between August 1, 2021, and January 5, 2022, and were at high risk for COVID-19 disease progression. Treatment patients were propensity matched with high-risk control patients with a diagnosis of COVID-19 in the same timeframe who did not receive casirivimab and imdevimab. Patients were followed for 30 days for collection of data on inpatient admissions, emergency department visits, and mortality. Risk of a 30-day healthcare utilization event was assessed and tested for statistical significance utilizing McNemar's test. RESULTS: A total of 585 patients who received treatment with subcutaneous casirivimab and imdevimab were matched with 585 patients who did not receive casirivimab and imdevimab therapy. Patients who received casirivimab and imdevimab had significantly lower risk of a 30-day all-cause inpatient admission event than untreated patients (relative risk reduction, 62.4%; P < 0.0001). Treated patients also had a significantly lower risk of 30-day all-cause emergency department visit than untreated subjects (relative risk reduction, 36.5%; P = 0.0021). There were 6 mortality events in the untreated group and no mortality events in the treatment group. CONCLUSION: This study provides evidence for the effectiveness of a subcutaneous casirivimab and imdevimab clinic in preventing progression of symptomatic mild to moderate COVID-19.
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Authors | Christian Rhudy, Samantha Bochenek, Justin Thomas, Gerald St James, Matthew Zeltner, Thom Platt |
Journal | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
(Am J Health Syst Pharm)
Vol. 80
Issue 3
Pg. 130-136
(Jan 24 2023)
ISSN: 1535-2900 [Electronic] England |
PMID | 36264659
(Publication Type: Journal Article)
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Copyright | © American Society of Health-System Pharmacists 2022. All rights reserved. For permissions, please e-mail: [email protected]. |
Chemical References |
- imdevimab
- casirivimab and imdevimab drug combination
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Topics |
- Humans
- Outpatients
- Cohort Studies
- Retrospective Studies
- COVID-19
- Disease Progression
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