Abstract | Background: Methods: We retrospectively assessed patients with recurrent SCLC who received AMR after chemoimmunotherapy at the Niigata Lung Cancer Treatment Group from August 2019 to February 2021. Results: This analysis included 30 patients. The median progression-free survival (PFS) and overall survival (OS) were 3.8 (95% CI: 2.7-4.2) and 10 (95% CI: 7.4-14.8) months, respectively. The median PFS and OS did not significantly differ between the sensitive and refractory groups [PFS; 3.1 (95% CI: 1.1-4.0) vs. 4.2 (95% CI: 2.3-4.8) months, P=0.1142, OS; 10.0 (95% CI: 5.2-14.8) vs. 10.4 (95% CI: 3.8-NE) months, P=0.5525]. The most common adverse event was grade ≥3 neutropenia, which occurred in 22 of 30 patients (73%), and 2 patients (7%) discontinued AMR due to adverse events. Conclusions: AMR after chemoimmunotherapy shows good clinical efficacy and safety in patients with recurrent SCLC.
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Authors | Kohei Kushiro, Satoshi Watanabe, Yuka Goto, Toshiya Fujisaki, Naohiro Yanagimura, Aya Ohtsubo, Satoshi Shoji, Koichiro Nozaki, Tomohiro Tanaka, Yu Saida, Yusuke Sato, Takeshi Ota, Jun Koshio, Yoshiki Hayashi, Takao Miyabayashi, Naoya Matsumoto, Kosuke Ichikawa, Kenichi Koyama, Toshiaki Kikuchi |
Journal | Translational lung cancer research
(Transl Lung Cancer Res)
Vol. 11
Issue 9
Pg. 1858-1865
(Sep 2022)
ISSN: 2218-6751 [Print] China |
PMID | 36248339
(Publication Type: Journal Article)
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Copyright | 2022 Translational Lung Cancer Research. All rights reserved. |