Abstract | BACKGROUND: METHODS: RESULTS: A total of 246 patients were included, of whom 150 received dexamethasone and tocilizumab, while 96 received dexamethasone alone. Acute respiratory distress syndrome was evident on admission in 226 patients, 56 of whom required mechanical ventilation (MV). Superinfections, mainly respiratory, were diagnosed in 59 patients, including 34/150 (23%) in Group 1 and 25/96 (26%) in Group 2 (p = 0.32). After multivariate analysis, the factors associated with a higher risk of superinfection included hematological malignancy (hazard ratio (HR): 2.47 (1.11-5.47), p = 0.03), MV (HR: 3.74 (1.92-7.26), p = 0.0001), and a higher SAPS-II score on admission (HR: 1.03 (1.01-1.06), p = 0.006). CONCLUSION:
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Authors | Fabrice Camou, Nahéma Issa, Mojgan Hessamfar, Olivier Guisset, Gaëlle Mourissoux, Stéphane Pedeboscq, Aimée Minot, Fabrice Bonnet |
Journal | Journal of clinical medicine
(J Clin Med)
Vol. 11
Issue 19
(Sep 22 2022)
ISSN: 2077-0383 [Print] Switzerland |
PMID | 36233432
(Publication Type: Journal Article)
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