Bisphosphonates are drugs used to treat bone disorders. The chronic use of
bisphosphonates is associated with the occurrence of medication-related
osteonecrosis of the jaw (MRONJ). Previous data reported the positive effects of
Geranylgeraniol on different cell types treated with
Bisphosphonates. Foregoing work done by our research group demonstrated the wound healing capacity of Fridericia chica (Bonpl.) L.G.Lohmann standardized
ethanol extract. Herein in vitro cytoprotective synergistic effect of the association of F. chica extract associated with an enriched
geranylgeraniol fraction on keratinocytes exposed to
zoledronic acid is reported. An association of F. chica at 1 and 5 µg/mL with
geranylgeraniol at 15 µg/mL, increased cell viability by 73.5% and 71.1%, respectively. This treatment did not increase
tumor cells viability; whereas the clonogenic potential assessment showed that, the association with F. chica (5 µg/mL) reversed the effects of
zoledronic acid on the cells. This study provides data for a potential treatment for MRONJ.