Comparison between chronic spontaneous urticaria and chronic induced urticaria on the efficacy of omalizumab treatment: A systematic review and meta-analysis.
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| Abstract |
This meta-analysis aimed to assess the efficacy of omalizumab in the treatment of refractory-to-antihistamines chronic induced urticaria (CIndU) in comparison with that of refractory-to-antihistamines chronic spontaneous urticaria (CSU). We retrieved interventional studies and observational studies on omalizumab efficacy to CIndU patients and efficacy comparison between CSU and CIndU both refractory to H1-antihistamines in electronic databases (accessed till May 2022). The odd ratio (OR) and 95% confidence interval (CI) was calculated with a random-effect model in this meta-analysis. The majority of patients with different CIndU subtypes gained complete or partial response and good safety after omalizumab treatment. A total of five studies with 355 CSU patients and 103 CIndU patients were included for the meta-analysis. There was no significant difference in the efficacy of omalizumab in the treatment of CSU and CIndU (OR -0.83, 95% CI [0.84, 2.21], P > 0.05). Based on the validity of omalizumab in the treatment of various CIndU subtypes and non-differential efficacy between CSU and CIndU, it is reasonable to list omalizumab as a third-line treatment of refractory CIndU.
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| Authors | Zhu-Han He, Shuo-Cheng Qiu, Zhi-Wei Huang, Guo-Qiang Zhang, Qing-Qing An, Feng Qu, Na Wang |
| Journal | Dermatologic therapy (Dermatol Ther) Vol. 35 Issue 12 Pg. e15928 (12 2022) ISSN: 1529-8019 [Electronic] United States |
| PMID | 36222320 (Publication Type: Meta-Analysis, Systematic Review, Journal Article, Review) |
| Copyright | © 2022 Wiley Periodicals LLC. |
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