Abstract | INTRODUCTION: there is evidence on the effectiveness and safety of tocilizumab (TZC) used in combination with systemic corticosteroids for severe SARS-CoV-2 pneumonia treatment. The purpose of this study was to describe epidemiological, clinical, and laboratory features as well as clinical outcome of patients receiving this combination therapy compared with those receiving only corticosteroids. METHODS: RESULTS: median age was 58 years old and 63.9% were females. High blood pressure was present in 36.1% and obesity in 54.6%. Survival in the cohort was 81.4%, with a median hospital stay of 19.0 days. Secondary infections were present in 47.4% of the cohort. Patients in the TZC group had a lower C reactive protein (CRP) at discharge, lower rate of multiple organ failure, better functional status at discharge and shorter hospital stay. In a bivariate analysis, no differences were found in mortality rate and secondary infections occurrence. When assessing clinical status as per WHO Ordinal Scale there was a significant difference in its variability from worsening to discharge (or 14 days), evidencing a better functional status in patients receiving TCZ. DISCUSSION: we were able to demonstrate its efficacy in reducing inflammatory biomarkers and a trend towards fewer days of hospitalization, with no impact on mortality.
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Authors | Nazareno Galvalisi, Vanina Pagotto, Valeria Tudanca, Paola Brunetti, Carla Tornatore, Lucila Villar, Francisco Allalla, Héctor Ferraro, Alejandro Schejtman, Flavio Rotryng |
Journal | Medicina
(Medicina (B Aires))
Vol. 82
Issue 5
Pg. 659-666
( 2022)
ISSN: 1669-9106 [Electronic] Argentina |
Vernacular Title | De las publicaciones a la práctica cotidiana: tocilizumab en pacientes con COVID-19 grave. |
PMID | 36220021
(Publication Type: Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Antibodies, Monoclonal, Humanized
- Biomarkers
- C-Reactive Protein
- tocilizumab
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Topics |
- Adrenal Cortex Hormones
- Adult
- Antibodies, Monoclonal, Humanized
- Biomarkers
- C-Reactive Protein
(analysis)
- Coinfection
- Female
- Humans
- Male
- Middle Aged
- Retrospective Studies
- SARS-CoV-2
- Treatment Outcome
- COVID-19 Drug Treatment
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