[New progress in diagnosis and treatment of HPV-positive oropharyngeal carcinoma].

Abstract

In recent years, the incidence of oropharyngeal carcinoma （OPC） is increasing, while the better prognosis of patients with Human papillomavirus （HPV） positive oropharyngeal carcinoma has been confirmed in a number of studies. There are a variety of detection methods for HPV-associated oropharyngeal carcinoma. Including P16 immunohistochemistry, Polymerase Chain Reaction （PCR） or In situ hybridization （ISH） detection of HPV DNA, HPV RNA, Revers transcriptase Polymerase Chain Reaction （RT PCR） was used to detect HPV RNA. The better prognosis of patients with HPV-positive oropharyngeal carcinoma has led to the emergence of a large number of degraded treatment trials. The traditional P16 test has certain limitations in the diagnosis of patients with HPV-positive oropharyngeal carcinoma. It is necessary to combine with other detection methods to accurately screen out patients with HPV-positive oropharyngeal carcinoma and better apply to degraded therapy. In this article, we will briefly introduce the trend of HPV-associated oropharyngeal carcinoma, the detection methods and the new progress of degraded treatment trials.

• Authors: Yamin Liu, Huaihong Chen
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 36 Issue 10 Pg. 802-806 (Oct 2022) ISSN: 2096-7993 [Print] China
• PMID: 36217663 (Publication Type: Journal Article)
• Copyright: Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

Chemical References

• Cyclin-Dependent Kinase Inhibitor p16
• DNA, Viral
• RNA

Topics

• Carcinoma, Squamous Cell (metabolism)
• Cyclin-Dependent Kinase Inhibitor p16 (metabolism)
• DNA, Viral (analysis)
• Humans
• Oropharyngeal Neoplasms (diagnosis, pathology, therapy)
• Papillomaviridae (genetics)
• Papillomavirus Infections (diagnosis)
• RNA