Hypoxic nonhealing
wounds are a common complication in chronic patients, and chronic
hypoxia is the main reason for delayed wound healing, so local
wound oxygenation may be an effective way to address this problem. Here, we proposed a system consisting of
oxygen-releasing
microsphere (GC) and self-healing
hydrogel (QGO). QGO/GC
hydrogel could promote survival, migration and tube formation of human umbilical vein endothelial cells under hypoxic conditions. Moreover, QGO/GC
hydrogels exhibited biocompatibility in vitro and in vivo. The hypoxic mouse
burn model further confirmed that QGO/GC
hydrogel could promote tissue repair by reducing
inflammation (TNF-α and IL-1β), increasing angiogenesis (CD31,
VEGF and α-SMA) and
collagen deposition. This study provided an effective
oxygen-releasing
hydrogel that could offer a simple and effective method for the clinical treatment of chronic hypoxic
wounds. STATEMENT OF SIGNIFICANCE:
Burn injury is caused by various exogenous factors such as friction, cold, radiations, electricity, chemicals, hot surfaces or liquids. Severe
burn can damage the entire skin layer, and the healing process is delayed due to an unbalanced inflammatory response, excessive
reactive oxygen species, lack of angiogenesis (insufficient nutrient and
oxygen availability), and susceptibility to
infection. In the present study, we proposed an
oxygen-releasing
hydrogel (QGO/GC). QGO/GC
hydrogel could promote survival, migration, and tube formation of human umbilical vein endothelial cells under hypoxic conditions. And QGO/GC
hydrogels could promote tissue repair by reducing
inflammation, increasing angiogenesis and
collagen deposition. This work provided an effective
oxygen-releasing
hydrogel for the clinical management of chronic hypoxic
wounds.