Abstract | INTRODUCTION: METHODS: The aim of the study was to evaluate the treatment effects and adverse events of Monterizine® (a combination of montelukast and levocetirizine); a total of 2,254 patients with perennial allergic rhinitis and asthma were prospectively enrolled from 60 hospitals nationwide in Korea. They were followed up for 3 (Period 1) or 6 months (Period 2). Total nasal symptom score (TNSS), satisfaction, and safety data were collected and compared to baseline. RESULTS: TNSS scores were analyzed for 2,254 subjects. At Period 1 (n = 2,024) and 2 (n = 1,861), the scores decreased significantly from baseline (-1.20 ± 2.49 and -1.63 ± 2.78, p < 0.001). The mean quality of life (QoL) was significantly improved at Period 1 and 2 relative to baseline (-3.75 ± 6.58, -4.83 ± 7.11, both p < 0.0001). There were no serious adverse drug reactions, but there were some minor reactions including nasopharyngitis (2.92%), rhinitis (0.37%), and somnolence (0.34%). CONCLUSIONS: TNSS score and QoL were significantly improved by 3-6 months' treatment with Monterizine without significant adverse reactions. These results indicate that Monterizine, as a combination drug, is effective and safe for improving nasal symptoms and quality of life in patients with allergic rhinitis who also have asthma.
|
Authors | Min-Hye Kim, Kyoung-Hee Sohn, Hye Jung Park, Young Hee Nam, Mi-Hye Kim, Jae-Woo Jung, Jae-Woo Kwon, Yoo Seob Shin, Jong-Sook Park, Young-Joo Cho, Choon-Sik Park, Byoung Whui Choi |
Journal | International archives of allergy and immunology
(Int Arch Allergy Immunol)
Vol. 183
Issue 12
Pg. 1251-1258
( 2022)
ISSN: 1423-0097 [Electronic] Switzerland |
PMID | 36209731
(Publication Type: Observational Study, Multicenter Study, Journal Article)
|
Copyright | © 2022 S. Karger AG, Basel. |
Chemical References |
- levocetirizine
- montelukast
- Acetates
- Quinolines
- Cyclopropanes
- Drug Combinations
|
Topics |
- Humans
- Quality of Life
- Acetates
(adverse effects)
- Quinolines
(adverse effects)
- Cyclopropanes
(therapeutic use)
- Rhinitis, Allergic
(drug therapy, chemically induced)
- Asthma
(drug therapy, chemically induced)
- Drug Combinations
- Treatment Outcome
|