Abstract |
Pathological biomarkers of dementia and Alzheimer's disease (AD) change decades before clinical symptoms. Common sensory and motor changes in aging adults may be early markers of neurodegeneration. We investigated if midlife sensory and motor functions in Beaver Dam Offspring Study (BOSS) participants (N = 1529) were associated with longitudinal changes in blood-based biomarkers of neurodegeneration (neurofilament light chain (NfL); total tau (TTau)) and AD ( amyloid beta (Aβ)). Mixed-effects models with baseline sensory and motor function as determinants and 10-year biomarker change as outcome were used. Participants with hearing impairment and worse motor function (among women) showed faster increases in NfL level over time (0.8% per year; 0.3% per year, respectively). There were no significant associations with TTau or Aβ. We found consistent relationships between worse baseline hearing and motor function with a faster increase in neurodegeneration, specifically serum NfL level. Future studies with longer follow-up should determine if sensory and motor changes are more reflective of general neurodegeneration than AD-specific pathology and whether sensory and motor tests may be useful screening tools for neurodegeneration risk.
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Authors | Adam J Paulsen, Carla R Schubert, Alex A Pinto, Richard J Chappell, Yanjun Chen, Karen J Cruickshanks, Corinne D Engelman, Luigi Ferrucci, Laura M Hancock, Sterling C Johnson, Natascha Merten |
Journal | Neurobiology of aging
(Neurobiol Aging)
Vol. 120
Pg. 177-188
(12 2022)
ISSN: 1558-1497 [Electronic] United States |
PMID | 36209638
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2022. Published by Elsevier Inc. |
Chemical References |
- Amyloid beta-Peptides
- Biomarkers
- Neurofilament Proteins
- tau Proteins
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Topics |
- Female
- Humans
- Alzheimer Disease
(pathology)
- Amyloid beta-Peptides
- Biomarkers
- Neurofilament Proteins
- tau Proteins
- Neurodegenerative Diseases
(pathology)
- Sensation
- Middle Aged
- Motor Skills
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