Biomimetic chitosan-derived bifunctional lubricant with superior antibacterial and hydration lubrication performances.

Abstract

The lubrication deficiency in joints is a major cause of osteoarthritis. One of the most commonly used treatment means is to inject artificial lubricants, but there is a potential risk of infection during the injection process. Therefore, developing artificial lubricants with dual functions of friction-reduction and antibacterial is urgent. In this work, a novel polysaccharide-derived lubricant with simultaneous anti-bacteria and water-lubrication properties, called CS-MPC-N, is developed by grafting 2‑methacryloyloxylethyl phosphorylcholine (MPC) and nisin peptide onto backbone of chitosan (CS). Compared to the control CS, CS-MPC-N exhibits good lubrication and friction-reduction properties because of its excellent water solubility. Especially, CS-MPC-N shows low friction coefficient (0.03 ∼ 0.05) at the sliding interfaces of artificial joints materials or even natural articular cartilages. Moreover, CS-MPC-N can effectively inhibit the proliferation of Staphylococcus aureu, exhibiting excellent antibacterial effect. This kind of novel polysaccharide-derived lubricant is expected to be used in treating infectious arthritis.

• Authors: Lumin Yang, Xiaoduo Zhao, Xiaozhu Liao, Rui Wang, Zengjie Fan, Shuanhong Ma, Feng Zhou
• Journal: Journal of colloid and interface science (J Colloid Interface Sci) Vol. 629 Issue Pt B Pg. 859-870 (Jan 2023) ISSN: 1095-7103 [Electronic] United States
• PMID: 36202029 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Chemical References

• Chitosan
• Lubricants
• Anti-Bacterial Agents
• Water

Topics

• Chitosan (pharmacology)
• Lubrication
• Lubricants (pharmacology, chemistry)
• Biomimetics
• Anti-Bacterial Agents (pharmacology)
• Water
• Friction