Real-world evidence of quality of life improvement in patients with distal ulcerative colitis treated by mesalazine: the Quartz study.

Abstract

BACKGROUND:

Distal ulcerative colitis (UC) is responsible for distressing symptoms and reduces quality of life (QoL). Oral and topical formulations of 5-amino-salicylic acid are the first line therapy for mild to moderate distal UC.

OBJECTIVE:

Our aim was to evaluate the impact of mesalazine treatment for mild to moderate ulcerative proctitis and proctosigmoiditis on patient QoL.

METHODS:

Ninety-three patients with mild to moderate ulcerative proctitis and proctosigmoiditis, initiating a treatment with Pentasa, were prospectively included. The primary endpoint was the change from baseline to W8 in patient health-related QoL (HRQoL) as measured by the Short Inflammatory Bowel Disease Questionnaire (SIBDQ) total score.

RESULTS:

More than 80% of patients were prescribed with a rectal formulation, either alone (47.9%) or with an oral formulation (35.1%), and 17.0% of patients were prescribed oral formulation alone. Mean SIBDQ score was improved at W8 in patients affected with mild and moderate disease ( P  < 0.001 versus baseline in both groups, as well as in patients who achieved clinical remission ( P  < 0.001). Patients who achieved clinical remission at W8 reached a mean change of +6.7 (±7.1), whereas those who did not achieve clinical remission had a mean change of +1.1 (±8.9). Seventy-five per cent of patients had an improvement of their disability index at W8. Fecal incontinence was also improved at W8.

CONCLUSION:

HRQoL measuring with the SIBDQ is proportionally related to disease activity in patients with distal UC treated with mesalazine.

• Authors: Thierry Paupard, Florent Gonzalez, Bénédicte Caron, Laurent Siproudhis, Laurent Peyrin-Biroulet
• Journal: European journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 34 Issue 12 Pg. 1203-1209 (12 01 2022) ISSN: 1473-5687 [Electronic] England
• PMID: 36165055 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Mesalamine
• Quartz
• N-(8-aminohexyl)-5-iodonaphthalene-1-sulfonamide
• Anti-Inflammatory Agents, Non-Steroidal

Topics

• Humans
• Mesalamine
• Colitis, Ulcerative (diagnosis, drug therapy, chemically induced)
• Quality of Life
• Quartz (therapeutic use)
• Proctocolitis (drug therapy)
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Ulcer (chemically induced)
• Inflammatory Bowel Diseases (drug therapy)