Reversible Cardiac Hypertrophy in Pulmonary Arterial Hypertension Treated With High-Dose Epoprostenol.

Abstract

Although current guidelines recommend the use of prostanoid infusion that includes epoprostenol for high-risk pulmonary arterial hypertension patients, epoprostenol has many adverse effects. We report a case of a heritable pulmonary arterial hypertension patient who had transient biventricular hypertrophy during high-dose administration of epoprostenol. In this case, biventricular hypertrophy with worsening of dyspnea was observed during the uptitration of epoprostenol. Inflammatory diseases and endocrine disorders were ruled out as causes of the ventricular hypertrophy. After epoprostenol was changed to intravenous treprostinil, the biventricular hypertrophy normalized, in connection with dyspnea improvement. The use of high-dose epoprostenol may contribute to cardiac hypertrophy.

• Authors: Keiichi Izumi, Takumi Inami, Kaori Takeuchi, Hanako Kikuchi, Ayumi Goda, Masaru Hatano, Takashi Kohno, Konomi Sakata, Junji Shibahara, Kyoko Soejima, Toru Satoh
• Journal: CJC open (CJC Open) Vol. 4 Issue 9 Pg. 816-819 (Sep 2022) ISSN: 2589-790X [Electronic] United States
• PMID: 36148261 (Publication Type: Case Reports)
• Copyright: © 2022 The Authors.