Initial Case Report of Cladorrhinum samala Mycotic Keratitis.

Abstract

PURPOSE:

The purpose of this study was to report the first case of keratitis caused by Cladorrhinum samala and review of the literature.

METHODS:

This was a case report and literature review.

RESULTS:

A 35-year-old immunocompetent man presented with pain, redness, and watering in the right eye 7 days after trauma with some foreign body. He was diagnosed with infectious keratitis, and a thorough microbiological workup was performed. Corneal scrapings were subjected to a potassium hydroxide (KOH) examination, Gram staining, bacterial (blood agar and Robertson cooked meat broth), and fungal culture (Sabouraud dextrose agar and brain-heart infusion agar). The KOH mount revealed septate fungal hyphae with irregular margins. Yellow-white nonsporulating mycelial growth was noted on the Sabouraud dextrose agar, which was identified as C. samala by sequencing. The patient responded to 5% natamycin and 1% voriconazole eye drops, and there was a formation of a corneal opacity in a period of 3 weeks.

CONCLUSIONS:

We report the first case of keratitis by C. samala, highlighting the emergence of a rare dematiaceous fungi causing keratitis and the role of molecular modalities in the diagnosis of nonsporulating fungi in suspected cases.

• Authors: Parakriti Gupta, Anchal Thakur, Shivaprakash M Rudramurthy, Amit Gupta, Anup Ghosh, Harsimran Kaur
• Journal: Cornea (Cornea) Vol. 41 Issue 10 Pg. 1302-1304 (Oct 01 2022) ISSN: 1536-4798 [Electronic] United States
• PMID: 36107849 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Culture Media
• Ophthalmic Solutions
• Natamycin
• Agar
• Glucose
• Voriconazole

Topics

• Adult
• Agar
• Corneal Ulcer (diagnosis, drug therapy, microbiology)
• Culture Media
• Eye Infections, Fungal (diagnosis, drug therapy, microbiology)
• Glucose
• Humans
• Keratitis (diagnosis, drug therapy, microbiology)
• Male
• Natamycin
• Ophthalmic Solutions
• Sordariales
• Voriconazole