Treatment of eating disorders: A systematic meta-review of meta-analyses and network meta-analyses.

Abstract

MONTELEONE, A.M., F. Pellegrino, G. Croatto, M. Carfagno, A. Hilbert, J. Treasure, T. Wade, C. Bulik, S. Zipfel, P. Hay, U. Schmidt, G. Castellini, A. Favaro, F. Fernandez-Aranda, J. Il Shin, U. Voderholzer, V. Ricca, D. Moretti, D. Busatta, G. Abbate-Daga, F. Ciullini, G. Cascino, F. Monaco, C.U. Correll and M. Solmi. Treatment of Eating Disorders: a systematic meta-review of meta-analyses and network meta-analyses. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2022.- Treatment efficacy for eating disorders (EDs) is modest and guidelines differ. We summarized findings/quality of (network) meta-analyses (N)MA of randomized controlled trials (RCTs) in EDs. Systematic meta-review ((N)MA of RCTs, ED, active/inactive control), using (anorexia or bulimia or eating disorder) AND (meta-analy*) in PubMed/PsycINFO/Cochrane database up to December 15th, 2020. Standardized mean difference, odds/risk ratio vs control were summarized at end of treatment and follow-up. Interventions involving family (family-based therapy, FBT) outperformed active control in adults/adolescents with anorexia nervosa (AN), and in adolescents with bulimia nervosa (BN). In adults with BN, individual cognitive behavioural therapy (CBT)-ED had the broadest efficacy versus active control; also, antidepressants outperformed active. In mixed age groups with binge-eating disorder (BED), psychotherapy, and lisdexamfetamine outperformed active control. Antidepressants, stimulants outperformed placebo, despite lower acceptability, as did CBT-ED versus waitlist/no treatment. Family-based therapy is effective in AN and BN (adolescents). CBT-ED has the largest efficacy in BN (adults), followed by antidepressants, as well as psychotherapy in BED (mixed). Medications have short-term efficacy in BED (adults).

• Authors: Alessio Maria Monteleone, Francesca Pellegrino, Giovanni Croatto, Marco Carfagno, Anja Hilbert, Janet Treasure, Tracey Wade, Cynthia M Bulik, Stephan Zipfel, Phillipa Hay, Ulrike Schmidt, Giovanni Castellini, Angela Favaro, Fernando Fernandez-Aranda, Jae Il Shin, Ulrich Voderholzer, Valdo Ricca, Davide Moretti, Daniele Busatta, Giovanni Abbate-Daga, Filippo Ciullini, Giammarco Cascino, Francesco Monaco, Christoph U Correll, Marco Solmi
• Journal: Neuroscience and biobehavioral reviews (Neurosci Biobehav Rev) Vol. 142 Pg. 104857 (11 2022) ISSN: 1873-7528 [Electronic] United States
• PMID: 36084848 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review, Systematic Review)
• Copyright: Copyright © 2022 Elsevier Ltd. All rights reserved.

Chemical References

• Antidepressive Agents

Topics

• Adolescent
• Adult
• Humans
• Antidepressive Agents (therapeutic use)
• Binge-Eating Disorder (drug therapy, psychology)
• Bulimia (drug therapy)
• Bulimia Nervosa
• Feeding and Eating Disorders (drug therapy)
• Network Meta-Analysis
• Meta-Analysis as Topic