Comparison of the Efficiency of Epidermal Growth Factor and Negative Pressure Wound Therapy in Diabetic Foot Patients.

Abstract

Advanced modalities are used for wounds where conventional treatment is insufficient in diabetic foot patients. In this study, we investigated the effects of using Epidermal growth factor (EGF) and NPWTmodalities alone or in combination on the frequency and level of amputation. In the retrospective study, which included 286 patients in total, 76 patients were referred with the decision of amputation or amputation was planned during hospitalization. After the treatments, amputation and distalization of amputation were found 73.3% and 33.3% in the conventional treatment patients. While 86.4% amp and 18.2% amp distalization were found in negative pressure wound therapy (NPWT) only patients, this rate was 52.4% and 90.5% in EGF + NPWT patients, 50% and 83.3% in EGF only patients. While amp and distalization rates were found to be significantly better in those receiving only EGF or EGF + NPWT (P = .015, P = .017 respectively for amputation and P = .000 for distalization), no difference was found in those receiving EGF and EGF + NPWT. As a result of our study, although npwt contributed positively to the number and level of amputations compared to conventional treatment, a significant improvement was found in the number and level of amps when EGF was used alone or combined with NPWT. With this result, EGF was thought to be an important treatment modality that should be evaluated in diabetic foot ulcers (DFUs) without amputation decision.

• Authors: Ahmet Çınar Yastı, Turgut Karaca, Murat Kendirci, Ali Emre Akgün, İbrahim Tayfun Şahiner, Merve Akın
• Journal: The international journal of lower extremity wounds (Int J Low Extrem Wounds) Vol. 22 Issue 1 Pg. 93-102 (Mar 2023) ISSN: 1552-6941 [Electronic] United States
• PMID: 36069057 (Publication Type: Journal Article)

Chemical References

• Epidermal Growth Factor

Topics

• Humans
• Epidermal Growth Factor
• Diabetic Foot (diagnosis, therapy, etiology)
• Negative-Pressure Wound Therapy
• Retrospective Studies
• Wound Healing
• Diabetes Mellitus