The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial.

Abstract

BACKGROUND:

Chitosan is one of dietary fiber that has received great attention in improving obesity-related markers, but little is known on its effects on adolescents.

OBJECTIVES:

To analyze the effects of chitosan supplementation on obesity-related cardiometabolic markers and appetite-related hormones in adolescents with overweight or obesity.

METHODS AND ANALYSIS:

A randomized clinical trial was performed on 64 adolescents with overweight and obesity, who were randomly allocated to receive chitosan supplementation (n = 32) or placebo as control (n = 32) for 12 weeks. Anthropometric measures, lipid and glycemic profiles, and appetite-related hormones were examined.

RESULTS:

Sixty-one participants completed study (chitosan = 31, placebo = 30). Chitosan supplementation significantly improved anthropometric indicators of obesity (body weight: - 3.58 ± 2.17 kg, waist circumference: - 5.00 ± 3.11 cm, and body mass index: - 1.61 ± 0.99 kg/m2 and - 0.28 ± 0.19 Z-score), lipid (triglycerides: - 5.67 ± 9.24, total cholesterol: - 14.12 ± 13.34, LDL-C: - 7.18 ± 10.16, and HDL-C: 1.83 ± 4.64 mg/dL) and glycemic markers (insulin: - 5.51 ± 7.52 μIU/mL, fasting blood glucose: - 5.77 ± 6.93 mg/dL, and homeostasis model assessment of insulin resistance: - 0.24 ± 0.44), and appetite-related hormones (adiponectin: 1.69 ± 2.13 ng/dL, leptin - 19.40 ± 16.89, and neuropeptide Y: - 41.96 ± 79.34 ng/dL). When compared with the placebo group, chitosan supplementation had greater improvement in body weight, body mass index (kg/m2 and Z-score), waist circumference, as well as insulin, adiponectin, and leptin levels. Differences were significant according to P-value < 0.05.

CONCLUSION:

Chitosan supplementation can improve cardiometabolic parameters (anthropometric indicators of obesity and lipid and glycemic markers) and appetite-related hormones (adiponectin, leptin, and NPY) in adolescents with overweight or obesity.

• Authors: Somaye Fatahi, Ali Akbar Sayyari, Masoud Salehi, Majid Safa, Mohammadhassan Sohouli, Farzad Shidfar, Heitor O Santos
• Journal: BMC pediatrics (BMC Pediatr) Vol. 22 Issue 1 Pg. 527 (09 05 2022) ISSN: 1471-2431 [Electronic] England
• PMID: 36064382 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2022. The Author(s).

Chemical References

• Adiponectin
• Blood Glucose
• Insulin
• Leptin
• Triglycerides
• Chitosan

Topics

• Adiponectin
• Adolescent
• Appetite
• Blood Glucose
• Body Mass Index
• Body Weight
• Cardiovascular Diseases
• Chitosan (pharmacology, therapeutic use)
• Dietary Supplements
• Double-Blind Method
• Humans
• Insulin (therapeutic use)
• Leptin
• Obesity
• Overweight
• Triglycerides