Abstract | BACKGROUND: METHODS: This was a population-based, retrospective cohort study of Olmsted County, Minnesota adults with advanced heart failure from 2007-2018. Difficulty with 9 activities of daily living was assessed by questionnaire. Predictors of difficulty were assessed by a proportional odds model. Associations of difficulty with activities of daily living with mortality and hospitalization were examined using Cox and Andersen-Gill models. RESULTS: Among 765 patients with advanced heart failure, 565 (73.9%) reported difficulty with activities of daily living at diagnosis. Of those, 257 (45%) had moderate and 148 (26%) had severe difficulty. Independent predictors of difficulty included female sex (odds ratio [OR] 1.73; 95% confidence interval [CI], 1.26-2.36; P = .001), older age (OR per 10-year increase 1.17; 95% CI, 1.05-1.31; P = .005), dementia (OR 1.85; 95% CI, 1.06-3.24; P = .031), depression (OR 1.75; 95% CI, 1.28-2.40; P = .001), and morbid obesity (OR 1.49; 95% CI, 1.04-2.13; P = .031). Estimated 2-year mortality was 61.5%, 64.2%, and 67.6% in patients with no/minimal, moderate, and severe difficulty, respectively. The adjusted hazard ratios (95% CI) for death were 1.08 (0.90-1.28) and 1.17 (0.95-1.43) for moderate and severe difficulty, respectively, vs no/minimal difficulty (P = .33). There were no statistically significant associations of difficulty with activities of daily living and hospitalization risks. CONCLUSIONS:
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Authors | Alexandria R Roy, Jill M Killian, Phillip J Schulte, Véronique L Roger, Shannon M Dunlay |
Journal | The American journal of medicine
(Am J Med)
Vol. 135
Issue 12
Pg. 1497-1504.e2
(12 2022)
ISSN: 1555-7162 [Electronic] United States |
PMID | 36063861
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2022 Elsevier Inc. All rights reserved. |
Topics |
- Humans
- Female
- Adult
- Activities of Daily Living
- Retrospective Studies
- Heart Failure
(epidemiology)
- Hospitalization
- Odds Ratio
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