Previous therapy with immune checkpoint inhibitor as a cause of hypothyroidism, myositis, and renal insufficiency in a candidate for allogeneic hematopoietic transplantation.
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| Abstract |
Treatment of neoplastic diseases resistant to conventional chemotherapies is still an open challenge. The increasing development of chemical molecules or monoclonal antibodies able to recognize precise molecular targets of cancer disease has played an increasingly important role in treating patients suffering from solid or hematological tumors, and constitutes the basis of so-called 'targeted therapy'. Immunotherapy has become a cornerstone for treating refractory or relapsed cancer disease patients after standard chemotherapies. Immune checkpoint (including PD-1) inhibitors are essential drugs that significantly improve the therapeutic possibilities for neoplastic patients. Still, foreseeable or unpredictable adverse effects can potentially arise during or after the end of therapy. Specifically, toxicity involving several organs is capable of delaying or preventing the continuation of programmed treatment, as described in this case, where we will discuss the possibility of toxicity affecting various organs (kidney, muscle tissue, and thyroid) attributed to nivolumab and which resulted in temporary ineligibility for allogeneic transplantation.
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| Authors | Andrea Duminuco, Alessandra Cupri, Giulio A Milone, Carmelita Marcantoni, Salvatore Leotta, Benedetta Esposito, Bruno Garibaldi, Annalisa Chiarenza, Giuseppe Milone |
| Journal | Transplant immunology (Transpl Immunol) Vol. 75 Pg. 101705 (12 2022) ISSN: 1878-5492 [Electronic] Netherlands |
| PMID | 36055435 (Publication Type: Case Reports) |
| Copyright | Copyright © 2022 Elsevier B.V. All rights reserved. |
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