Femistina versus Canephron as a prevention of urinary tract infections after midurethral sling surgery - Non-inferiority study.

Abstract

OBJECTIVE:

Urinary tract infection (UTI) is relatively common post-operative complication following midurethral sling placement (MUS), even in cases where intraoperative antibiotic prophylaxis was given. The primary aim of this study was to investigate the non-inferiority of Femistina as compared with Canephron in reducing symptomatic UTI in first six months following surgery.

STUDY DESIGN:

A sample size of 144 patients per group was established, to provide at least 90% power to demonstrate the non-inferiority of phytodrug Femistina versus Canephron as a prevention of post-MUS urinary tract infection.

RESULTS:

Women suffering from stress urinary incontinence and mixed urinary incontinence (MUI) with predominant SUI symptoms as confirmed by urodymamics (n = 320) were randomized in a 1:1 ratio to Femistina (40 mg, oral, twice daily for 20 days) or Canephron (3 × 5 ml taken orally-three times daily for 4 weeks). Both groups were homogenous for age, type of operation (only TOT outside-in) and severity of illness as indicated by ICIQ-SF questionnaire. We found that symptoms of UTI were significantly lower in patients receiving Femistina. During first 6 months after surgery UTI was confirmed in only 10 patients receiving Femistina (6,25%) when compared to 25 (15,63%) subjects receiving Canephron, p < 0.007.

CONCLUSION:

Femistina is not inferior to Canephron in preventing lower urinary tract infection after midurethral sling surgery.

• Authors: Ewa Rechberger, Andrzej Wróbel, Beata Kulik-Rechberger, Paweł Miotła, Tomasz Rechberger
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 277 Pg. 71-76 (Oct 2022) ISSN: 1872-7654 [Electronic] Ireland
• PMID: 36027670 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2022. Published by Elsevier B.V.

Chemical References

• Plant Extracts
• canephron N

Topics

• Female
• Humans
• Plant Extracts
• Suburethral Slings (adverse effects)
• Urinary Incontinence, Stress (complications, prevention & control, surgery)
• Urinary Incontinence, Urge (complications)
• Urinary Tract Infections (etiology, prevention & control)