In the past two decades, minimally invasive spine surgery (MISS) techniques have been developed for spinal surgery. Historically, minimizing invasiveness in
decompression surgery was initially reported as a MISS technique. In recent years, MISS techniques have also been applied for spinal stabilization techniques, which were defined as minimally invasive spine stabilization (MISt), including percutaneous
pedicle screws (PPS) fixation, lateral lumbar interbody fusion, balloon
kyphoplasty, percutaneous
vertebroplasty, cortical bone trajectory, and cervical
total disc replacement. These MISS techniques typically provide many advantages such as preservation of paraspinal musculature, less blood loss, a shorter
operative time, less
postoperative pain, and a lower
infection rate as well as being more cost-effective compared to traditional open techniques. However, even MISS techniques are associated with several limitations including technical difficulty, training opportunities, surgical cost, equipment cost, and radiation exposure. These downsides of surgical treatments make
conservative treatments more feasible option. In the future, medicine must become "minimally invasive" in the broadest sense-for all patients, conventional surgeries, medical personnel, hospital
management, nursing care, and the medical economy. As a new framework for the treatment of
spinal diseases, the concept of minimally invasive spinal treatment (MIST) has been proposed.