Abstract | BACKGROUND: So far, no medical treatment is available for cholesteatoma (C) and the only effective therapy is complete surgical removal, but recurrence is common even after surgical treatment. While C is classically divided into two clinical phenotypes, congenital and acquired, only a few studies have focused on its potential biomarkers. This study aims to revise the literature to identify which biomarkers can define the endotype of C. METHODS: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis ( PRISMA) process to identify published experimental articles about molecular biomarkers in C. RESULTS: KGF and its receptor, MMP-9, KRT-1, KRT-10, and MIF might be considered biomarkers of recurrence, whereas Ki-67, TLR-4, RANKL, IL17, MMP-2, MMP-9, IL6, TNF-α, should be considered more specifically as biomarkers of bony erosion. CONCLUSIONS: These results are interesting especially from a prognostic point of view, nevertheless more studies are needed to search new biomarkers of C that could completely change not only the therapeutic standards of the disease, but also the clinical history of C itself in the era of precision medicine.
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Authors | Elena Cantone, Claudio Di Nola, Eugenio De Corso, Michele Cavaliere, Giusi Grimaldi, Anna Rita Fetoni, Gaetano Motta |
Journal | Journal of personalized medicine
(J Pers Med)
Vol. 12
Issue 8
(Aug 21 2022)
ISSN: 2075-4426 [Print] Switzerland |
PMID | 36013295
(Publication Type: Journal Article, Review)
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