Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases.

Abstract

Cardiovascular diseases (CVDs) are a group of diseases in which the common denominator is the affection of blood vessels, heart tissue, and heart rhythm. The genesis of CVD is complex and multifactorial; therefore, approaches are often based on multidisciplinary management and more than one drug is used to achieve the optimal control of risk factors (dyslipidemia, hypertension, hypertrophy, oxidative stress, endothelial dysfunction, inflammation). In this context, allicin, a sulfur compound naturally derived from garlic, has shown beneficial effects on several cardiovascular risk factors through the modulation of cellular mechanisms and signaling pathways. Effective pharmacological treatments for CVD or its risk factors have not been developed or are unknown in clinical practice. Thus, this work aimed to review the cellular mechanisms through which allicin exerts its therapeutic effects and to show why it could be a therapeutic option for the prevention or treatment of CVD and its risk factors.

• Authors: José L Sánchez-Gloria, Abraham S Arellano-Buendía, Juan G Juárez-Rojas, Fernando E García-Arroyo, Raúl Argüello-García, Fausto Sánchez-Muñoz, Laura G Sánchez-Lozada, Horacio Osorio-Alonso
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 23 Issue 16 (Aug 13 2022) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 36012349 (Publication Type: Journal Article, Review)

Chemical References

• Disulfides
• Sulfinic Acids
• allicin

Topics

• Cardiovascular Diseases (drug therapy, prevention & control)
• Disulfides (therapeutic use)
• Garlic
• Humans
• Sulfinic Acids (pharmacology, therapeutic use)