Abstract | OBJECTIVES: We prospectively evaluated the efficacy and safety of microwave ablation (MWA) combined with ethanol injection (EI) in solitary nodular retrosternal goiters (RSGs). METHODS: From November 2018 to November 2020, 72 patients diagnosed with solitary nodular RSG were treated by ultrasound-guided MWA with EI. Patients were followed up at 1, 3, 6, and 12 months and every 6-12 months thereafter by ultrasound and contrast-enhanced ultrasound (CEUS). The nodule volume, volume reduction ratio (VRR), neck circumference, symptom score, and cosmetic grading score were recorded to evaluate the treatment efficacy. RESULTS: All patients successfully underwent treatment. The mean initial nodule volume was 71.25 mL ± 61.61 mL, which decreased significantly to 7.47 mL ± 9.19 mL at a mean follow-up time of 23.89 months ± 7.66 months (range 15-39 months) with a mean VRR of 90.99% ± 7.52%. The neck circumference, symptom score, and cosmetic grading score significantly decreased from 36.94 cm ± 3.04 cm to 35.06 cm ± 2.84 cm, from 3.78 ± 1.19 to 0.36 ± 0.63, and from 3.42 ± 0.76 to 1.13 ± 0.37, at the 12 months after treatment, respectively (all 7 p < 0.001). Of all the nodules, eight (11.1%) received a second ablation. No major complications occurred. CONCLUSION: Ultrasound-guided MWA combined with EI is an effective and safe treatment for solitary nodular RSG and may be a potential alternative to surgery in selected patients, especially for those who are ineligible or unwilling to receive surgical treatment. KEY POINTS: • MWA combined with EI is an effective and safe approach for the treatment of solitary nodular RSG. • This treatment should be conducted by experienced physicians. • It provides a potential alternative to surgery for solitary nodular RSG in patients who are ineligible or unwilling to receive surgical treatment.
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Authors | Yingying Li, Xinyang Li, Jing Xiao, Lin Yan, Menglu Li, Mingbo Zhang, Yukun Luo |
Journal | European radiology
(Eur Radiol)
Vol. 33
Issue 2
Pg. 752-762
(Feb 2023)
ISSN: 1432-1084 [Electronic] Germany |
PMID | 35976394
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s), under exclusive licence to European Society of Radiology. |
Chemical References |
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Topics |
- Humans
- Prospective Studies
- Microwaves
(therapeutic use)
- Treatment Outcome
- Ultrasonography, Interventional
- Goiter
(surgery)
- Ethanol
- Catheter Ablation
(adverse effects)
- Thyroid Nodule
(diagnosis)
- Retrospective Studies
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