Rituximab as maintenance therapy following remission induction in relapsing or refractory systemic lupus erythematosus.

Abstract

OBJECTIVE:

To investigate the efficacy and safety of rituximab (RTX) maintenance therapy compared with traditional immunosuppressive agent (ISA) maintenance therapy in patients with relapsing or refractory SLE.

METHODS:

It is a prospective observational non-randomized cohort study. The study enrolled SLE patients in four centres who had received at least one course of RTX induction treatment. Patients with a clinical response to RTX were divided into two groups based on their maintenance therapy in the first 12 months: the RTX group and the ISA group. The relapse-free survival times were compared between the two groups. Univariate and multivariate analyses were conducted to identify predictive factors for disease relapse.

RESULTS:

Among the 82 patients included in the cohort, 67 (81.7%) patients had a clinical response at 6 months. RTX maintenance therapy was applied in 34 (50.7%) patients and ISA maintenance therapy was applied in the remaining 33 (49.3%) patients. After a median follow-up of 24 months, a total of 13 (19.4%) patients had experienced disease relapse, comprising three in the RTX group and 10 in the ISA group. Patients in the RTX group had a higher relapse-free survival rate than patients in the ISA group. Multivariate analysis identified hydroxychloroquine use, RTX maintenance therapy and haematological system involvement as independent predictors for sustained remission.

CONCLUSION:

This multicentre prospective cohort study demonstrated that long-term RTX maintenance therapy has high efficacy and acceptable safety in relapsing or refractory SLE patients who had a clinical response to RTX induction therapy.

• Authors: Xiaochan Chen, Xiaowei Shi, Han Xue, Honghua Lv, Lishi Yu, Xiudi Wu, Qiaohong Wang, Huaxiang Wu, Fei Han, Jing Xue
• Journal: Rheumatology (Oxford, England) (Rheumatology (Oxford)) Vol. 62 Issue 3 Pg. 1145-1152 (03 01 2023) ISSN: 1462-0332 [Electronic] England
• PMID: 35976105 (Publication Type: Observational Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: [email protected].

Chemical References

• Rituximab
• Immunosuppressive Agents

Topics

• Humans
• Rituximab (therapeutic use)
• Cohort Studies
• Prospective Studies
• Treatment Outcome
• Retrospective Studies
• Immunosuppressive Agents (therapeutic use)
• Lupus Erythematosus, Systemic (drug therapy)
• Remission Induction