Abstract | Background: Aims and Objective: Materials and Methods: Biopsies/blocks of oral cavity lesions were retrieved from the archives of the department. Normal oral mucosa (5 cases), oral epithelial dysplastic (60 cases) and different grades of OSCC (60 cases) evaluated by hematoxylin and eosin sections. Immunohistochemical analysis was done on the blocks and expression of E-cadherin and Vimentin was recorded. Results: Our study included various grades of OED, OSCC and normal mucosa as control cases. The mean age of OED and OSCC was 49 and 56 years, respectively, with male predominance. Tobacco habit was present in approximately 90% cases, and buccal mucosa was the most commonly involved site in oral cavity with whitish patch and ulceroproliferative lesions being the common clinical presentations respectively. In OED, downregulation and altered localization of e-cadherin (81.6%) and increased expression of vimentin (52.3%) along with their concurrent increase in the stroma represent epithelial mesenchymal transition. In OSCC, reduction in expression (<50%) for e-cadherin (56.6%) with altered localization for e-cadherin was seen in 88.3% of OSCC along with neoexpression of vimentin in the epithelial cells was seen in 68.3% suggestive of mesenchymal phenotypic modification (P = 0.05). Conclusion: It is very crucial to evaluate the invasiveness of dysplasia and tumor with specific molecular biomarker that may help in early prediction of malignancy and also guide in deciding best treatment strategy for established cases of malignancy.
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Authors | Nagiredla Puneeta, Tummidi Santosh, Isha Mishra, Pravin Gaikwad, Anshuta Sahu |
Journal | Journal of oral and maxillofacial pathology : JOMFP
(J Oral Maxillofac Pathol)
2022 Apr-Jun
Vol. 26
Issue 2
Pg. 285-286
ISSN: 0973-029X [Print] India |
PMID | 35968190
(Publication Type: Journal Article)
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Copyright | Copyright: © 2022 Journal of Oral and Maxillofacial Pathology. |