Abstract |
Osimertinib, the third generation of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, responds well to advanced non-small-cell lung cancer (NSCLC) with the EGFR T790M mutation. However, resistance to osimertinib would inevitably occur. We report a case of an advanced NSCLC patient after osimertinib resistance who was successfully treated by high-dose furmonertinib ( AST2818) at 160 mg. The patient initially received the GCP regimen for 11 months and displayed partial response. The patient received osimertinib 80 mg at the time of progression with a stable clinical and radiological response lasting only 7 months. Subsequently, she was commenced on furmonertinib 160 mg once daily. After 2 weeks of furmonertinib, the patient's tumor was markedly smaller on a follow-up chest CT scan, and her respiratory symptoms also improved. What shocked us was that after a month's re-examination of the cranial MRI, the intracranial lesions wholly disappeared. This report provides a case of the successful rescue of osimertinib-resistant NSCLC patients by oral administration of high-dose furmonertinib 160 mg daily, providing a new treatment option for osimertinib-resistant patients.
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Authors | Daoan Cheng, Shuxian Tang, Dong Li, Weiqing Zhao, Wei Wei, Cheng Fang, Mei Ji |
Journal | Anti-cancer drugs
(Anticancer Drugs)
Vol. 33
Issue 8
Pg. 768-772
(09 01 2022)
ISSN: 1473-5741 [Electronic] England |
PMID | 35946524
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
- Acrylamides
- Aniline Compounds
- Indoles
- Protein Kinase Inhibitors
- Pyridines
- Pyrimidines
- osimertinib
- aflutinib
- ErbB Receptors
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Topics |
- Acrylamides
- Aniline Compounds
- Carcinoma, Non-Small-Cell Lung
(diagnostic imaging, drug therapy, genetics)
- ErbB Receptors
(genetics)
- Female
- Humans
- Indoles
- Lung Neoplasms
(drug therapy, genetics, pathology)
- Mutation
- Protein Kinase Inhibitors
(therapeutic use)
- Pyridines
- Pyrimidines
- Salvage Therapy
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