Severe aplastic anaemia after serial vaccinations for SARS-CoV-2, pneumococcus and seasonal influenza.

Abstract

We present a 67-year-old woman who developed progressive pancytopenia over 10 months, concomitant with administration of severe adult respiratory syndrome coronavirus-2 (SARS-CoV-2), pneumococcal and influenza vaccines. She developed mild leukopenia ∼2 weeks after the SARS-CoV-2 mRNA vaccine sequence, with progressive symptoms after subsequent vaccines, eventually developing severe aplastic anaemia (SAA). While there have been several reports of vaccine-related SAA, at time of submission, our case is the first reported to develop after the Moderna mRNA SARS-CoV-2 vaccine, as well as the first to document the gradual development of SAA over the course of many vaccine exposures. Physicians should be cognizant of vaccine-associated SAA, considering current widespread coronavirus disease 2019 vaccination efforts.

• Authors: Xiao Wang, Dorottya Laczko, Gabriel C Caponetti, Susan Rabatin, Daria V Babushok
• Journal: EJHaem (EJHaem) Vol. 3 Issue 3 Pg. 983-988 (Aug 2022) ISSN: 2688-6146 [Electronic] United States
• PMID: 35941884 (Publication Type: Case Reports)
• Copyright: © 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.