RBM3 is an outstanding cold shock protein with multiple physiological functions beyond hypothermia.

Abstract

RNA-binding motif protein 3 (RBM3), an outstanding cold shock protein, is rapidly upregulated to ensure homeostasis and survival in a cold environment, which is an important physiological mechanism in response to cold stress. Meanwhile, RBM3 has multiple physiological functions and participates in the regulation of various cellular physiological processes, such as antiapoptosis, circadian rhythm, cell cycle, reproduction, and tumogenesis. The structure, conservation, and tissue distribution of RBM3 in human are demonstrated in this review. Herein, the multiple physiological functions of RBM3 were summarized based on recent research advances. Meanwhile, the cytoprotective mechanism of RBM3 during stress under various adverse conditions and its regulation of transcription were discussed. In addition, the neuroprotection of RBM3 and its oncogenic role and controversy in various cancers were investigated in our review.

• Authors: Yajie Hu, Yang Liu, Xin Quan, Wenxuan Fan, Bin Xu, Shize Li
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 237 Issue 10 Pg. 3788-3802 (10 2022) ISSN: 1097-4652 [Electronic] United States
• PMID: 35926117 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 Wiley Periodicals LLC.

Chemical References

• Cold Shock Proteins and Peptides
• RBM3 protein, human
• RNA-Binding Proteins

Topics

• Cold Shock Proteins and Peptides (genetics, metabolism)
• Cold Temperature
• Cold-Shock Response
• Humans
• Hypothermia (metabolism)
• Neuroprotection
• RNA-Binding Proteins (metabolism)