Effect of 1% malic acid spray on diabetes mellitus-induced xerostomia: A randomized clinical trial.

Abstract

OBJECTIVE:

To evaluate the effectiveness of topical sialogogue spray containing 1% malic acid in the treatment of xerostomia in patients with type 2 diabetes mellitus.

MATERIAL AND METHODS:

A randomized double-blind controlled clinical trial was conducted on 52 patients with type 2 diabetes mellitus suffering from xerostomia. Patients were assigned equally to test group who received a topical sialogogue spray containing 1% malic acid and control group who received a placebo spray. Both groups were instructed to use the spray on demand for 2 weeks. The Summated Xerostomia Inventory-Dutch Version questionnaire (SXI-D) and the unstimulated salivary flow rate were evaluated for all patients at baseline, 2 and 4 weeks after malic acid/placebo application.

RESULTS:

At 2 week's follow-up, the unstimulated salivary flow rate increased significantly from 0.059 ± 0.024 to 0.191 ± 0.064 and from 0.055 ± 0.026 to 0.078 ± 0.032 for test and control groups, respectively, with a statistically significant difference favoring the test group. SXI-D scores showed a significant decrease from 10.73 ± 2.22 to 8.38 ± 2.28 in the test group (p < 0.05), while in the control group it decreased from 10.62 ± 1.75 to 10.23 ± 1.48 (p > 0.05).

CONCLUSION:

A sialogogue spray containing 1% malic acid increased the unstimulated salivary flow rate in patients with type 2 diabetes mellitus suffering from xerostomia.

• Authors: Shaimaa A Muhamed, Eglal M Moussa, Noha K Aboasy, Yasmin Y Gaweesh
• Journal: Oral diseases (Oral Dis) (Aug 01 2022) ISSN: 1601-0825 [Electronic] Denmark
• PMID: 35913424 (Publication Type: Journal Article)
• Copyright: © 2022 Wiley Periodicals LLC.