Abstract | INTRODUCTION: AREAS COVERED: A systematic literature review retrieved articles, which describe the interaction between CYP2C19 genotype and clinical outcomes following IS or TIA when treated with clopidogrel. The review documents efforts to identify optimal antiplatelet regimens and explores the value genotype guided antiplatelet therapy. The work outlines the contemporary understanding of clopidogrel metabolism and appraises evidence linking CYP2C19 LoF variants with attenuated platelet inhibition and poorer outcomes. EXPERT OPINION: There is good evidence that CYP2C19 LoF allele carriers of Han-Chinese ancestry have increased risk for further vascular events following TIA or IS when treated with clopidogrel. The evidence base is less certain in other populations. The expansion of pharmacogenetics into routine clinical practice will facilitate further research and help tailor other aspects of secondary prevention.
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Authors | John H McDermott, Marc Leach, Dwaipayan Sen, Craig J Smith, William G Newman, Philip M Bath |
Journal | Expert review of clinical pharmacology
(Expert Rev Clin Pharmacol)
Vol. 15
Issue 7
Pg. 811-825
(Jul 2022)
ISSN: 1751-2441 [Electronic] England |
PMID | 35912831
(Publication Type: Journal Article, Systematic Review)
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Chemical References |
- Platelet Aggregation Inhibitors
- Clopidogrel
- CYP2C19 protein, human
- Cytochrome P-450 CYP2C19
- Ticlopidine
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Topics |
- Clopidogrel
(adverse effects)
- Cytochrome P-450 CYP2C19
(genetics)
- Genotype
- Humans
- Ischemic Attack, Transient
(drug therapy, genetics, prevention & control)
- Ischemic Stroke
- Platelet Aggregation Inhibitors
(pharmacology)
- Stroke
(etiology, genetics)
- Ticlopidine
(pharmacology)
- Treatment Outcome
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