The role of guggulsterone on the NF-κB pathway in inflammatory bowel disease: preclinical evidence.

Abstract

Guggulsterone, a phytosterol in the herb Commiphora wightii (Arn.) Bhandari, has been used in the treatment of diseases such as hyperlipidemia, arthritis and atherosclerosis. It has attracted significant research interest because of its pharmacological properties, especially its anti-inflammatory nature. It can be used for the treatment of inflammatory bowel disease (IBD), a disease characterized by chronic inflammation and damage in the gastrointestinal tract. In various preclinical studies, it inhibited NF-κB, an important pathway in the pathophysiology of IBD. This review summarizes the preclinical studies on this topic for providing more insights to the mechanism by which guggulsterone exerts its effect.

• Authors: Sk Sujitha Priya, Ankita Jha, Rajappan Chandra Satish Kumar, Sarvesh Sabarathinam
• Journal: Future science OA (Future Sci OA) Vol. 8 Issue 6 Pg. FSO803 (Jul 2022) ISSN: 2056-5623 [Print] England
• PMID: 35909996 (Publication Type: Journal Article)
• Copyright: © 2022 The Authors.