Abstract | Objective: Studies have shown that sex differences in lean mass, concentrations of sex hormones, and lifestyles influence cle health and glucose metabolism. We evaluated the sex-specific association between low muscle mass and glucose fluctuations in hospitalized patients with type 2 diabetes mellitus (T2DM) receiving continuous subcutaneous insulin infusion (CSII) therapy. Methods: A total of 1084 participants were included. Body composition was determined by dual-energy X-ray absorptiometry. Intraday blood glucose fluctuation was estimated by the Largest amplitude of glycemic excursions (LAGE) and standard deviation of blood glucose (SDBG). Results: The prevalence of low muscle mass was higher in males than in females (p<0.001). There was a significant sex-specific interaction between the status of low muscle mass and glucose fluctuations (LAGE and SDBG) (p for interaction=0.025 and 0.036 for SDBG and LAGE, respectively). Among males, low muscle mass was significantly associated with a higher LAGE and SDBG (difference in LAGE: 2.26 [95% CI: 1.01 to 3.51], p < 0.001; difference in SDBG: 0.45 [95% CI: 0.25 to 0.65], p < 0.001) after adjustment for HbA1c, diabetes duration, hyperlipidemia, diabetic peripheral neuropathy, diabetic nephropathy, and cardiovascular disease. These associations remained significant after further adjustment for age and C-peptide. Among females, low muscle mass was not associated with LAGE or SDBG after adjustment for all covariates. Conclusion: The prevalence of low muscle mass was higher in males than in females. Low muscle mass was significantly associated with higher LAGE and SDBG among males, but not females.
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Authors | Xiulin Shi, Wenjuan Liu, Lulu Zhang, Fangsen Xiao, Peiying Huang, Bing Yan, Yiping Zhang, Weijuan Su, Qiuhui Jiang, Mingzhu Lin, Wei Liu, Xuejun Li |
Journal | Frontiers in endocrinology
(Front Endocrinol (Lausanne))
Vol. 13
Pg. 913207
( 2022)
ISSN: 1664-2392 [Print] Switzerland |
PMID | 35909561
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2022 Shi, Liu, Zhang, Xiao, Huang, Yan, Zhang, Su, Jiang, Lin, Liu and Li. |
Chemical References |
- Blood Glucose
- Insulin
- Glucose
|
Topics |
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Type 2
(epidemiology)
- Female
- Glucose
- Humans
- Insulin
- Male
- Muscles
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