Abstract | BACKGROUND: METHODS: A retrospective analysis of patients initially treated for LANPC from November 2016 to March 2019 was performed: trial group received CCRT + E and control group received CCRT. Prognoses and adverse effects were evaluated. RESULTS: Eighty-eight patients were included: 43 received CCRT + E and 45 received CCRT. The median follow-up time was 54.0 (range: 8.0-64.0) months. The survival data of the CCRT + E and CCRT groups were as follows: 3-year progression-free survival (PFS) rates, 81.4% and 63.6% (hazard ratio [HR] 0.418, 95%CI 0.181-0.963, P = 0.034); 3-year distant metastasis-free survival (DMFS) rates, 88.3% and 77.3% (HR 0.370, 95%CI 0.132-1.039, P = 0.049); 3-year overall survival rates, 88.2% and 81.9% (HR 0.437, 95%CI 0.151-1.260, P = 0.114); and 3-year locoregional failure-free survival rates, 87.8% and 86.9% (HR 0.795, 95%CI 0.242-2.616, P = 0.705). Three months after radiotherapy, the complete response (CR) rates of cervical lymph node regression were 97.7% and 82.2% for the CCRT + E and CCRT groups (P = 0.041). The corresponding CR rates were 100% and 80.0% for lymph node necrosis (P = 0.001) and 100% and 85.2% for extranodal extension (P = 0.041). The CCRT + E group had higher incidence of grade 3/4 leukopenia (32.6% vs. 13.3%, P = 0.031), with similar results for late toxicity. CONCLUSIONS: CCRT + E significantly prolonged 3-year PFS and DMFS in LANPC, and patients had better lymph node regression.
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Authors | Yuanxiu Yin, Ziyan Zhou, Zhiru Li, Mingjun Shen, Yating Qin, Chaolin Yang, Rensheng Wang, Min Kang |
Journal | Radiation oncology (London, England)
(Radiat Oncol)
Vol. 17
Issue 1
Pg. 135
(Jul 29 2022)
ISSN: 1748-717X [Electronic] England |
PMID | 35906636
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Endostatins
- Recombinant Proteins
- endostar protein
- Cisplatin
|
Topics |
- Antineoplastic Combined Chemotherapy Protocols
- Carcinoma
(therapy)
- Chemoradiotherapy
(methods)
- Cisplatin
- Endostatins
(therapeutic use)
- Humans
- Nasopharyngeal Carcinoma
(pathology, therapy)
- Nasopharyngeal Neoplasms
(pathology)
- Recombinant Proteins
- Retrospective Studies
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