Measuring and estimating insulin resistance in clinical and research settings.

Abstract

The article discusses how to measure insulin resistance in muscle, liver, and adipose tissue in human participants. The most frequently used methodologies to evaluate insulin resistance are described in detail starting from the gold standard, that is, the euglycemic hyperinsulinemic clamp, to the intravenous glucose tolerance test, surrogate indices based on fasting measurements, or dynamic tests (such as oral glucose or mixed meal tolerance tests). The accuracy, precision, and reproducibility of the tests as well as cutoff values are reported.

• Authors: Amalia Gastaldelli
• Journal: Obesity (Silver Spring, Md.) (Obesity (Silver Spring)) Vol. 30 Issue 8 Pg. 1549-1563 (08 2022) ISSN: 1930-739X [Electronic] United States
• PMID: 35894085 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 The Author. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).

Chemical References

• Blood Glucose
• Insulin

Topics

• Blood Glucose
• Glucose Clamp Technique
• Glucose Intolerance
• Glucose Tolerance Test
• Humans
• Insulin
• Insulin Resistance (physiology)
• Reproducibility of Results