Abstract | Objectives: Methods: 847 neonates with pneumonia were included in this study, of which 511 neonates were diagnosed with sepsis. Neonates were divided into the sepsis group and the nonsepsis group. All neonates underwent extensive and necessary clinical and laboratory tests. CAR was calculated as serum C-reactive protein (ng/ml)/ albumin (mg/ml). All statistical analyses were performed using the statistical package SPSS 24.0, as appropriate. Results: Compared with the nonsepsis group, neonates with sepsis have a higher CAR (P < 0.001). Further analysis showed that the prevalence of neonates with sepsis increased significantly from 41.0% in the low CAR group (CAR ≤ 0.024 × 10-3) to 80.0% in the high CAR group (CAR > 0.024 × 10-3) (P < 0.001). Correlation analysis showed that there was a strong positive correlation between CAR and PCT (r = 0.452, P < 0.001), nSOFA (r = 0.267, P < 0.001), and the prolonged length of hospital stay (r = 0.311, P < 0.001). Multiple logistic regression showed that CAR was an independent risk factor for the presence of sepsis in neonates with pneumonia. Receiver operating characteristic curve analysis revealed that CAR had adequate discriminatory power in predicting sepsis in neonates with pneumonia (area under curve (AUC) = 0.76, 95% CI 0.73-0.79, P < 0.001). Conclusions: CAR can be used as a new marker to identify sepsis in neonates with pneumonia.
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Authors | Ping Kang, Wen Kang, Yi Li, Tiewei Li |
Journal | Mediators of inflammation
(Mediators Inflamm)
Vol. 2022
Pg. 4711018
( 2022)
ISSN: 1466-1861 [Electronic] United States |
PMID | 35873709
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 Ping Kang et al. |
Chemical References |
- Biomarkers
- C-Reactive Protein
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Topics |
- Biomarkers
- C-Reactive Protein
(metabolism)
- Humans
- Infant, Newborn
- Pneumonia
(diagnosis)
- Prognosis
- ROC Curve
- Retrospective Studies
- Sepsis
(diagnosis)
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